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INTRINSAFree Consultation

What Intrinsa is and what it is used for

Intrinsa is a transdermal patch which constantly releases small amounts of testosterone that is absorbed through your skin into the bloodstream. The testosterone in Intrinsa is the same hormone as that produced naturally in men and women. Decreases in testosterone have been associated with low sexual desire, reduced sexual thoughts and reduced sexual arousal. All or any of these problems can cause personal distress or relationship difficulties. The medical term for this condition is Hypoactive Sexual Desire Disorder, also known as HSDD.

Intrinsa is used to treat HSDD. Intrinsa is intended for use by women up to the age of 60 years who have a low sexual desire which is causing distress or concern, who may have had both of their ovaries removed or have had their womb removed (hysterectomy), and are receiving estrogen therapy.

Before you take Intrinsa

Do not use Intrinsa

• if you are allergic (hypersensitive) to testosterone or any of the other ingredients of Intrinsa.
• if you know that you have had in the past, currently have, or think that you might have, breast cancer or any other cancer which your doctor has described as being caused or stimulated by the female hormone estrogen
• if you have other conditions that your doctor may consider not appropriate for the use of estrogen and/or testosterone.

You must consult the doctor before if you have a history of heart, liver or kidney disease, if you are diabetic, as testosterone may lower blood glucose levels, if you have a history of excessive adult acne, body or facial hair, hair loss, enlargement of the clitoris or voice deepening or hoarseness.

The efficacy of Intrinsa is reduced if your estrogen therapy is of a certain type ('conjugated equine estrogens'). Therefore, you need to discuss your type of estrogen with your doctor, who could advise you which type of estrogen is suitable together with Intrinsa. If you stop estrogen therapy you must also stop using Intrinsa. Keep in mind that estrogens should be administered for the shortest possible duration.

It is not known whether Intrinsa increases the risk of breast cancer. Your doctor will carefully monitor you with regard to breast cancer.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines.

Take particular care if you are taking medicines containing blood-thinning (anticoagulant) treatment.

Intrinsa is only indicated for women in their menopause after the ovaries and uterus have been removed. Do not use Intrinsa if you are, or suspect that you may be pregnant or are able to become pregnant, because it may cause harm to the unborn child. Do not use Intrinsa in case of breast-feeding because it may cause harm to the child.

How to take Intrinsa

Intrinsa should be replaced twice weekly (each 3 to 4 days). The active substance is released from the patch constantly over 3 to 4 days and is absorbed through your skin. Always use Intrinsa exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure of the instructions or if you want any more information.

The patch should be stuck onto your lower abdomen, below your waist and not on the breasts or bottom.

The skin at the attachment site must be clean and dry, as smooth as possible, not cut or irritated and preferably free from hair. Only one patch can be worn at a time.

If estrogen patches are being used, the patch and the estrogen patch cannot overlap.

How to stick on the patch

Step 1 Tear open the sachet. Do not use scissors as you may accidentally damage the patch. Remove the patch. Apply the patch immediately after removing it from the sachet.

Step 2 While holding the patch, remove half of the protective liner that covers the sticky part of the patch. Avoid touching the sticky side of the patch with your fingers.

Step 3 Apply the sticky side of the patch to the selected area onto your skin. Press the sticky side of the patch firmly into place for about 10 seconds.

Step 4 Fold back the patch and carefully remove the other half of the liner. Press the entire patch firmly against your skin with the palm of your hand for about 10 seconds. Use your fingers to make sure the edges of the patch stick to the skin. If an area of the patch lifts, apply pressure to that area.

You may shower, bath, swim and exercise as normal while wearing the patch. The patch is designed to remain in place during these times. However, do not scrub the area where the patch has been placed too hard. If a patch does begin to come off, you may be able to make it stick again by pressing on it firmly. If you cannot get the patch to stick successfully, remove the loose patch and use a new patch.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible Side Effects

Like all medicines, Intrinsa can cause side effects.

Tell your doctor immediately if you experience hair loss, enlargement of the clitoris, an increase in the amount of hair on the chin or upper lip, voice deepening or hoarseness, although these side effects may be mild. They are usually reversible if Intrinsa treatment is discontinued.

If you notice any skin reactions at the site of application such as redness, oedema, or blistering. In case of severe application site reaction, the treatment should be discontinued.

The following side effects may occur very commonly: rash/irritation/itching/redness at the site of the skin where the patch is applied and an increase in the amount of hair on the chin or upper lip

The following side effects may occur commonly: hair loss, acne, migraine, insomnia, voice deepening or hoarseness, breast pain, weight gain, abdominal pain.

If any of the side effects become serious or if you notice any other side effects, please tell your doctor.